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Trump's tariff threat a grim reminder of turbulent trade in first administrationARTHEx-01 by ARTHEx Biotech for Myotonic Dystrophy: Likelihood of ApprovalALEXANDRIA, Va. (AP) — Google, already facing a possible breakup of the company over its ubiquitous search engine , is fighting to beat back another attack by the U.S. Department of Justice alleging monopolistic conduct, this time over technology that puts online advertising in front of consumers. The Justice Department and Google made closing arguments Monday in a trial alleging Google's advertising technology constitutes an illegal monopoly. Javascript is required for you to be able to read premium content. Please enable it in your browser settings.

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NEW YORK (AP) — U.S. stocks rose to records Tuesday after Donald Trump’s latest talk about tariffs created only some ripples on Wall Street, even if they could roil the global economy were they to take effect. The S&P 500 climbed 0.6% to top the all-time high it set a couple weeks ago. The Dow Jones Industrial Average added 123 points, or 0.3%, to its own record set the day before, while the Nasdaq composite gained 0.6% as Microsoft and Big Tech led the way. Stock markets abroad mostly fell after President-elect Trump said he plans to impose sweeping new tariffs on Mexico, Canada and China once he takes office. But the movements were mostly modest. Stock indexes were down 0.1% in Shanghai and nearly flat in Hong Kong, while Canada’s main index edged down by less than 0.1%. Trump has often praised the use of tariffs , but investors are weighing whether his latest threat will actually become policy or is just an opening point for negotiations. For now, the market seems to be taking it more as the latter. The consequences otherwise for markets and the global economy could be painful. Unless the United States can prepare alternatives for the autos, energy products and other goods that come from Mexico, Canada and China, such tariffs would raise the price of imported items all at once and make households poorer, according to Carl Weinberg and Rubeela Farooqi, economists at High Frequency Economics. They would also hurt profit margins for U.S. companies, while raising the threat of retaliatory tariffs by other countries. And unlike tariffs in Trump’s first term, his latest proposal would affect products across the board. General Motors sank 9%, and Ford Motor fell 2.6% because both import automobiles from Mexico. Constellation Brands, which sells Modelo and other Mexican beer brands in the United States, dropped 3.3%. The value of the Mexican peso fell 1.8% against the U.S. dollar. Beyond the pain such tariffs would cause U.S. households and businesses, they could also push the Federal Reserve to slow or even halt its cuts to interest rates. The Fed had just begun easing its main interest rate from a two-decade high a couple months ago to offer support for the job market . While lower interest rates can boost the economy, they can also offer more fuel for inflation. “Many” officials at the Fed’s last meeting earlier this month said they should lower rates gradually, according to minutes of the meeting released Tuesday afternoon. The talk about tariffs overshadowed another mixed set of profit reports from U.S. retailers that answered few questions about how much more shoppers can keep spending. They’ll need to stay resilient after helping the economy avoid a recession, despite the high interest rates imposed by the Fed to get inflation under control. A report on Tuesday from the Conference Board said confidence among U.S. consumers improved in November, but not by as much as economists expected. Kohl’s tumbled 17% after its results for the latest quarter fell short of analysts’ expectations. CEO Tom Kingsbury said sales remain soft for apparel and footwear. A day earlier, Kingsbury said he plans to step down as CEO in January. Ashley Buchanan, CEO of Michaels and a retail veteran, will replace him. Best Buy fell 4.9% after likewise falling short of analysts’ expectations. Dick’s Sporting Goods topped forecasts for the latest quarter thanks to a strong back-to-school season, but its stock lost an early gain to fall 1.4%. Still, more stocks rose in the S&P 500 than fell. J.M. Smucker had one of the biggest gains and climbed 5.7% after topping analysts’ expectations for the latest quarter. CEO Mark Smucker credited strength for its Uncrustables, Meow Mix, Café Bustelo and Jif brands. Big Tech stocks also helped prop up U.S. indexes. Gains of 3.2% for Amazon and 2.2% for Microsoft were the two strongest forces lifting the S&P 500. All told, the S&P 500 rose 34.26 points to 6,021.63. The Dow gained 123.74 to 44,860.31, and the Nasdaq composite climbed 119.46 to 19,174.30. In the bond market, Treasury yields held relatively steady following their big drop from a day before driven by relief following Trump’s pick for Treasury secretary. The yield on the 10-year Treasury inched up to 4.29% from 4.28% late Monday, but it’s still well below the 4.41% level where it ended last week. In the crypto market, bitcoin continued to pull back after topping $99,000 for the first time late last week. It’s since dipped back toward $91,000, according to CoinDesk. It’s a sharp turnaround from the bonanza that initially took over the crypto market following Trump’s election. That boom had also appeared to have spilled into some corners of the stock market. Strategists at Barclays Capital pointed to stocks of unprofitable companies, along with other areas that can be caught up in bursts of optimism by smaller-pocketed “retail” investors. AP Business Writer Elaine Kurtenbach contributed.

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“We’re aware of the civil allegations and Jay-Z’s really strong response to that,” NFL (National Football League) commissioner Roger Goodell said on Wednesday after the conclusion of the league’s winter meetings. “We know the litigation is happening now. From our standpoint, our relationship is not changing with them, including our preparations for the next Super Bowl.” A woman who previously sued musician Sean “Diddy” Combs, alleging she was raped at an awards show after-party in 2000 when she was 13 years old, amended the lawsuit on Sunday to include a new allegation that Jay-Z was also at the party and participated in the sexual assault. Jay-Z, real name Shawn Carter, said the rape allegation made against him is part of an extortion attempt. The 24-time Grammy Award winner called the allegations “idiotic” and “heinous in nature” in a statement released by Roc Nation. The NFL teamed up with Jay-Z’s Roc Nation in 2019 for events and social activism. The league and the entertainment company extended their partnership a few months ago. Kendrick Lamar will perform the Super Bowl halftime show at The Caesars Superdome in New Orleans on February 9. Roc Nation and Emmy-winning producer Jesse Collins will serve as co-executive producers of the halftime show. Beyonce, who is married to Jay-Z, will perform at halftime of the Baltimore Ravens-Houston Texans game at Christmas. “I think they’re getting incredibly comfortable not just with the Super Bowl but other events they’ve advised us on and helped us with,” Mr Goodell said. “They’ve been a big help in the social justice area to us on many occasions. They’ve been great partners.”

If Americans, especially Conservatives, may have voted for Donald Trump in order to curb down foreign immigration, that's probably not happening anytime soon, as Vivek Ramaswamy , Trump's comrade-in-arms, has recently triggered a MAGA civil war over his latest tweet, where he has said that the reason US companies recruit foreign engineers instead of Americans is not because of an IQ deficit, but because of the basic 'culture'. ET Year-end Special Reads What kept India's stock market investors on toes in 2024? India's car race: How far EVs went in 2024 Investing in 2025: Six wealth management trends to watch out for The reason top tech companies often hire foreign-born & first-generation engineers over “native” Americans isn’t because of an innate American IQ deficit (a lazy & wrong explanation). A key part of it comes down to the c-word: culture. Tough questions demand tough answers & if... — Vivek Ramaswamy (@VivekGRamaswamy) December 26, 2024 Although there could be multiple explanations of the long Tweet that the upcoming Department of Government Efficiency co-head has posted, Conservatives are already triggered by this foreign-origin individual targeting the 'American culture', even though some of them were rooting for Ramaswamy and Trump during the US Presidential election season.What is Vivek Ramaswamy's controversial post-Christmas tweet all about? However, reports suggest that Ramaswamy has opened up and addressed some his life's core issues in this post, something that he has faced in his tough teenage years. He was born to Indian immigrant parents in Cincinnati's suburban areas, and according to Ramaswamy himself, did not have much money growing up, even though his parents were both in standard avenue of services. In a recent podcast, he has said that his experience with public schools where he studied, had not been great, where being a focused academic and model student was not a rewarding choice, at least not among his peers. All his thoughts may have piled up in the recent post-Christmas tweet that he posted, that the Conservatives are spewing fire over. 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The current President-elect of the United States is Donald Trump, after his win in the US elections 2024. #sr_widget.onDemand p, #stock_pro.onDemand p{font-size: 14px;line-height: 1.28;} .onDemand .live_stock{left:17px;padding:1px 3px 1px 5px;font-size:12px;font-weight:600;line-height:18px;top:9px} #sr_widget.onDemand .sr_desc{margin:0 auto 0;} #sr_widget.onDemand .sr_desc{color: #024d99;margin-top:10px;} #sr_widget.onDemand .crypto .live_stock .lb-icon{8px 6px 5px 3px !important} #sr_widget.crypto.onDemand a.text{border-bottom:1px solid #ccc;padding-bottom:5px;display:block;width:100%} #sr_widget.onDemand .sr_desc .text p, #stock_pro.onDemand .sr_desc .text p{font-size:12px;font-weight:400;} (You can now subscribe to our Economic Times WhatsApp channel)Disclaimer Statement: This content is authored by a 3rd party. The views expressed here are that of the respective authors/ entities and do not represent the views of Economic Times (ET). 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X To post this comment you must Log In/Connect with: The Economic Times or Fill in your details: Will be displayed Will not be displayed Will be displayed Share this Comment: Post to Twitter { "@context": "https://schema.org", "@type": "NewsArticle", "inLanguage":"en", "keywords" : ["vivek ramaswamy tweet","vivek ramaswamy","vivek ramaswamy news","department of government efficiency","vivek ramaswamy republican","US companies recruitment","american culture","US Presidential election 2024","US Presidential election season"], "headline": "Was this incident responsible for Vivek Ramaswamy's outbursts against American culture that eventually led", "description": "Vivek Ramaswamy, the biggest Trump loyalist during the US Presidential election campaign, and the co-head of a federal department in the upcoming Republican administration at the White House, has triggered a MAGA civil war on Twitter, where he targeted some key aspects of American culture. Here's what's so shocking about it", "datePublished": "2024-12-29T18:29:00+05:30", "dateModified": "2024-12-29T18:29:00+05:30", "url":"https://economictimes.indiatimes.com/news/international/us/was-this-incident-responsible-for-vivek-ramaswamys-outbursts-against-american-culture-that-eventually-led-to-maga-civil-war/articleshow/116769468.cms", "mainEntityOfPage":"https://economictimes.indiatimes.com/news/international/us/was-this-incident-responsible-for-vivek-ramaswamys-outbursts-against-american-culture-that-eventually-led-to-maga-civil-war/articleshow/116769468.cms", "articleSection" : "News", "articleBody":"If Americans, especially Conservatives, may have voted for Donald Trump in order to curb down foreign immigration, that's probably not happening anytime soon, as Vivek Ramaswamy, Trump's comrade-in-arms, has recently triggered a MAGA civil war over his latest tweet, where he has said that the reason US companies recruit foreign engineers instead of Americans is not because of an IQ deficit, but because of the basic 'culture'.Although there could be multiple explanations of the long Tweet that the upcoming Department of Government Efficiency co-head has posted, Conservatives are already triggered by this foreign-origin individual targeting the 'American culture', even though some of them were rooting for Ramaswamy and Trump during the US Presidential election season.What is Vivek Ramaswamy's controversial post-Christmas tweet all about? However, reports suggest that Ramaswamy has opened up and addressed some his life's core issues in this post, something that he has faced in his tough teenage years. He was born to Indian immigrant parents in Cincinnati's suburban areas, and according to Ramaswamy himself, did not have much money growing up, even though his parents were both in standard avenue of services. In a recent podcast, he has said that his experience with public schools where he studied, had not been great, where being a focused academic and model student was not a rewarding choice, at least not among his peers. All his thoughts may have piled up in the recent post-Christmas tweet that he posted, that the Conservatives are spewing fire over. FAQs:Is Vivek Ramaswamy a Republican?Vivek Ramaswamy's political affiliation has been quite clear, with the fact that he is an avid Donald Trump supporter, and has been quite active during the US Presidential campaign.Who is the current President-elect of the United States? The current President-elect of the United States is Donald Trump, after his win in the US elections 2024.", "image": { "@type": "ImageObject", "url": "https://img.etimg.com/thumb/msid-116769507,resizemode-4,width-1200,height-900,imgsize-1553716,overlay-economictimes/articleshow.jpg", "width": 1200, "height": 900 }, "author": { "@type": "Thing", "name": "The Feed" }, "publisher": { "@type": "NewsMediaOrganization", "name": "Economic Times", "logo": { "@type": "ImageObject", "url": "https://img.etimg.com/thumb/msid-76939477,width-600,height-60,quality-100/economictimes.jpg", "width": 600, "height": 60 } } } { "@context": "https://schema.org/", "@type" : "WebPage", "name" : "Was this incident responsible for Vivek Ramaswamy's outbursts against American culture that eventually led", "speakable" : { "@type": "SpeakableSpecification", "cssSelector" : [".article_wrap h1", ".artSyn h2"] }, "url": "https://economictimes.indiatimes.com/news/international/us/was-this-incident-responsible-for-vivek-ramaswamys-outbursts-against-american-culture-that-eventually-led-to-maga-civil-war/articleshow/116769468.cms" } {"@context":"https://schema.org","@type":"FAQPage","mainEntity":[{"@type":"Question","name":"Is Vivek Ramaswamy a Republican?","acceptedAnswer":{"@type":"Answer","text":"Vivek Ramaswamy's political affiliation has been quite clear, with the fact that he is an avid Donald Trump supporter, and has been quite active during the US Presidential campaign."}},{"@type":"Question","name":"Who is the current President-elect of the United States?","acceptedAnswer":{"@type":"Answer","text":"The current President-elect of the United States is Donald Trump, after his win in the US elections 2024."}}]} //set iframe height on load (function(){ $('#toispecials-iframe').height($(window).height()); })(); /* function scrollIframeToTop() { setTimeout(function() { $('body, html').animate({ scrollTop: $menuEl.offset().top }, 800); }, 500); } scrollIframeToTop(); */ var countryCode = window.geoinfo && geoinfo.CountryCode; if (countryCode === "IN"){ $('.inSideInd').addClass("show"); $('.outsideInd').remove(); } else{ $('.outsideInd').addClass("show"); $('.inSideInd').remove(); } window.onload = function() { // setFont(); }; Stories you might be interested in Subscribe to our ET Investment Opportunities SUBMIT if(window.location.href.indexOf('.com/articleshow/') != -1){ grxEvent('event', {'event_category': 'articleshow', 'event_action': 'url_issue referrer: ' + document.referrer, 'event_label': window.location.href}); }

Trastuzumab rezetecan is under clinical development by and currently in Phase I for Transitional Cell Carcinoma (Urothelial Cell Carcinoma). According to GlobalData, Phase I drugs for Transitional Cell Carcinoma (Urothelial Cell Carcinoma) have an 83% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. Trastuzumab rezetecan overview Trastuzumab rezetecan (SHRA-1811) is under development for the treatment of HER2 expressing or mutated advanced malignant solid tumor, human epidermal growth factor receptor 2 positive breast cancer (HER2+ breast cancer), HER2-negative Advanced Breast Cancer, metastatic breast cancer, metastatic biliary cancer (BTC), advanced non-small cell lung cancer, metastatic colorectal cancer, gastric cancer, cervical cancer, recurrent ovarian cancer and endometrial cancer and adenocarcinoma of the gastroesophageal junction. It comprises of the anti-HER2 antibody trastuzumab, a cleavable linker, and the topoisomerase I inhibitor payload SHR169265. It is administered by intravenous and parenteral route. The drug candidate is an antibody drug conjugate which acts by targeting cells expressing tyrosine kinase type cell surface receptor HER2. Jiangsu Hengrui Medicine overview (Jiangsu Hengrui) is a biopharmaceutical company that focuses on the research, development, manufacture, and distribution of novel pharmaceutical products. Its product portfolio includes anti-tumor drugs, surgical drugs, contrast agents, angiomyocardiac drugs, and antibiotics. The company is also developing pipeline products for the treatment of cancer, Crohn’s disease, anemia, diabetes, atopic dermatitis, chronic bone disease, blood pressure, and hypercholesterolemia. Jiangsu Hengrui has R&D facilities in China, the US, and Japan. The company offers products through its sales and distribution network in China, the US, Japan, Germany Switzerland and Australia. Jiangsu Hengrui is headquartered in Lianyungang, Jiangsu Province, China. For a complete picture of Trastuzumab rezetecan’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .